(Unbeatable Squirrel Girl II#5 (fb)) – A new student at Empire State University, Mary Mahajan interacted in class with Nancy Whitehead, Cody and Doreen Green.

(Unbeatable Squirrel Girl II#2 (fb) – BTS) – Mary Mahajan woke up one morning trapped in the 1960s. She adapted, forming a relationship with local Tim, and began existing as best she could in a new time. Mary made plans to invest in the stock market.

(Unbeatable Squirrel Girl II#3 (fb) – BTS) – Mary tried releasing a line of "future products" but no one was willing to buy them, thinking she could speed the development of technology and accelerate the creation of the time machine to get home.

(Unbeatable Squirrel Girl II#2) – Squirrel Girl and Tippy-Toe recognized Mary, who was using headphones, as being trapped in the past like them. Sitting down at Café Papillon, they talked about their situations and wondered if others were trapped in the past with them.

(Unbeatable Squirrel Girl II#3) – Mary attended a meeting held by Squirrel Girl with other college students trapped in the past, including Trish. Mary admitted her attempt at trying to sell products. Suddenly, Dr. Doom and Nancy Whitehead, using a time machine, appeared in the room from the future (Mary's present day). To demonstrate how the future could be impacted by time travel, Doom upgraded Nancy's phone and she accessed her off-line Wikipedia to confirm that Doom would soon take over the planet, rechristening it Planet Doom in the future. Doom attacked SG, who saved the students by tossing them all into a pool four blocks away before following to regroup.

(Unbeatable Squirrel Girl II#4) – Mary, Nancy and Squirrel Girl talked about plans to defeat Doom, including stealing his time machine. Mary suggested they use it to retrieve future technology and soon recruited the other students to help her make EMPs, revealing her love for doomsday weapons. After they constructed EMPs, they tried using them on Dr. Doom but the devices didn't work. A time traveler then arrived with seemingly 0another Dr. Doom, unmasking to reveal she was an elderly Squirrel Girl from Earth-61340 and "Doom" was revealed as Cody.

(Unbeatable Squirrel Girl II#5) – As Cody admitted he was the one behind sending the students back in time to eliminate his competition for grades, Dr. Doom opened fire on the others and Tippy had Mary and Nancy grab the EMPs and head outside, where they pretended to be filming a movie, keeping suspicious civilians away. Soon, Dr. Doom was defeated and Old Lady Squirrel Girl kept Mary from getting the time gun. Returned to the present, Mary realized that Doreen Green was Squirrel Girl.

(Unbeatable Squirrel Girl II#10 (fb) – BTS) – Tomas Lara-Perez began dating Mary and she soon learned he was the hero Chipmunk Hunk. They had three successful dates.

(Unbeatable Squirrel Girl II#10) – After finishing a conflict with Mole Man, who had sunken many of the world's most famous buildings, Squirrel Girl had Nancy, Mary, Chipmunk Hunk and Koi Boi all help Doreen put dirt back under the missing buildings as squirrels in Iron Man suits lifted the buildings back up. Mary wondered if she could steal some of the Iron Man tech.

(Unbeatable Squirrel Girl Beats Up the Marvel Universe GN - BTS) – Tomas talked about Mary taking notes in class.

(Unbeatable Squirrel Girl II#17) – Mary, Tomas, Ken, Nancy, Brain Drain and Doreen attended an ethics class hosted by guest lecturer Melissa Morbeck.

(Unbeatable Squirrel Girl II#19) – Koi Boi, Chipmunk Hunk, Mary Mahajan and Nancy Whitehead rushed into Morbeck's home with the police, past mind-controlled zoo animals, and found Squirrel Girl battling armed bears and Melissa Morbeck already gone. Weeks went by and Squirrel Girl grew paranoid that animals watching her were controlled by Morbeck, leading to an awkward encounter with Howard the Duck in front of Mary, Tippy and Nancy. In time, Morbeck had a plane with a banner announce that Dr. Doom was attacking the city with mosquitoes, frightening the public.

(Unbeatable Squirrel Girl II#20) – As they discussed the threat of Morbeck, Tippy-Toe gathered squirrels Davis, Naseemo, Porkums and Li'l Busta to help protect Mary, Tomas, Ken, Nancy and Doreen from getting bitten, leaving Professor Twigs, Danni and Catherine "the Cashew" Pawsworth behind. Morbeck had Doombear, a bear in a Dr. Doom costume, reveal itself to Squirrel Girl and her allies, and Morbeck spoke through the bear, revealing she planned to frame Squirrel Girl for the animal and mosquito attacks across the city. Squirrel Girl challenged Morbeck to face her directly and Morbeck did so, speaking over a megaphone and knowing that the media was recording every move. SG, Chipmunk Hunk and Koi Boi battled the animal army while Mary and Nancy worked on creating an EMP. Tippy shaved off her fur to pose as a rat then ran directly up to Morbeck and detonated the EMP, shorting out her ability to control the animals. Morbeck was arrested.

(Unbeatable Squirrel Girl II#21 (fb) – BTS) – Mary visited her family during a break from school.

(Unbeatable Squirrel Girl II#22 – BTS) – Nancy and Doreen went to the Savage Land and Tomas and Mary, though jealous, agreed to take notes for them.

(Unbeatable Squirrel Girl II#33 (fb) – BTS) – Tomas told Mary about a secret power he had: to scream in sonics when frightened.

(Unbeatable Squirrel Girl II#32) – On a date with Mary, Tomas was invited by Nancy and Doreen to join them in an escape room. Tomas, Brian, Mary, Ken, Nancy and Doreen met Kraven at the airport and invited him to the escape room. At the facility, they saw Howard the Duck leaving then met the owner of the facility, who had them each of them choose a super-hero name. Mary chose "Super-Powers Woman." Calling their team the Justice Pals, the group worked together to get out of the room but they soon discovered the walls were closing in on them.

(Unbeatable Squirrel Girl II#33) – Squirrel Girl helped the others escape the trap by using her super-strong jaws then they all took time to recount their individual skills. Mary listed her skills as engineering, bombs, death-traps and engineering bombs and death-traps. As they solved more puzzles, Mary asked Kraven if he knew Dr. Doom. In one room, Mary defused a bomb. Mary and Kraven exposed Tomas' scream to help defeat Mojo II, the man responsible for their death-traps. Outside, Kraven was tackled by police. SG tried standing up for him but ended up getting them all arrested.

(Unbeatable Squirrel Girl II#34) – Bragging about the likelihood that she would one day likely be a super-villain, Mary waited in the jail cell for their trial to begin. After time in their cell, the group was taken to court, represented by She-Hulk, while Courtney Alaska prosecuted them. In the end, Squirrel Girl and her friends were found innocent and Kraven was found guilty but he broke out of custody and ran for it.

(Unbeatable Squirrel Girl II#35) – Haskel the squirrel guided Nancy, Mary, Tomas, Ken and Brain Drain toward a battle where Squirrel Girl was defending Kraven against Spider-Man. Kraven bid his friends farewell, promising to return as their ally another day.

(Unbeatable Squirrel Girl II#37) – After someone posing as Squirrel Girl faked her death, a funeral was held and Doreen's friends attended the fake funeral, with Doreen and Nancy in disguise. They saw many heroes and villains give testimonials of the impact SG had on their lives then they showed footage of "Squirrel Girl" dying in a battle alongside the Avengers against the Octobliterator. Back at home, Nancy, Doreen, Tippy, Ken, Mary, Brian and Tomas discussed options and they determined the impostor was likely a Skrull.

(Unbeatable Squirrel Girl II#38) – Doreen, Brian, Tomas, Ken, Mary, Tippy and Nancy used personal questions to determine that they weren't Skrulls.

(Unbeatable Squirrel Girl II#39) – Nancy, Doreen, Mary, Tippy, Ken, Tomas and Brian met for coffee and discussed how to detect Skrulls. Mary suggested building a weapons system but the others decided to hack Databus, the A.I. belonging to Tony Stark. The allies worked together to find Tony Stark, who was being held captive by a Skrull woman.

(Unbeatable Squirrel Girl II#40) – Squirrel Girl and her friends listened to G'illian Blax'zthor, the Skrull, share her life story about being a defector who was starting a new life and they agreed to help her, with SG even convincing Iron Man to support them. They held a press conference, announcing SG was alive and a Skrull had died. Months later, SG and her friends welcomed a group of Skrull refugees to Earth.

(Unbeatable Squirrel Girl II#43) – Squirrel Girl took Tippy-Toe, Brain Drain, Nancy, Koi Boi, Chipmunk Hunk and Mary Mahajan to the Negative Zone to visit Allene Green then SG disappeared, magically transported back to Earth.

(Unbeatable Squirrel Girl II#46) – Brain Drain, Nancy, Mary, Tippy, Ken and Tomas returned from the Negative Zone to see that Doreen and Ratatoskr had defeated an invasion of Frost Giants. Loki came to arrest Ratatoskr but Nancy and Doreen argued she should remain free.

(Unbeatable Squirrel Girl II#47) – Mary, her relationship with Tomas growing more serious, bantered with Tomas, Ken, Nancy, Tippy and Mew about how she wanted to repurpose unidentified super-villain doomsday devices. They realized Brain Drain was missing and went looking for him. They realized Brain Drain was sending them coded messages that informed them Melissa Morbeck had kidnapped him. The friends turned on the news and realized that Morbeck had revealed publicly that Squirrel Girl was Doreen Green, and Nancy hugged Doreen as she grieved the loss of her privacy. They saw that SG's apartment had been blown up then several of SG's villains attacked, including Blockchain, EpicCrimez, Bug-Eyed Voice, Swarm and Boomerang.

(Unbeatable Squirrel Girl II#48) – Squirrel Girl convinced her foes to retreat, stating they wouldn't want to know what she was like if she actually wanted revenge. After Mary called in a report to lure the media away, they returned to the blown-up apartment. SG took Nancy, Tippy, Ken, Mary and Tomas back to confront Morbeck in Central Park, where they were soon joined by Iron Man. Iron Man arrived but Morbeck stole his armor and then began calling herself Iron Ring before she attacked with Whiplash, Leader, Baron Mordo, Fin Fang Foom, Taskmaster, Dormammu, M.O.D.O.K. and Dr. Doom. Fin Fang Foom grabbed Mary and Nancy then Brain Drain, in a new enhanced armor, was forced to attack his friends.

(Unbeatable Squirrel Girl II#49) – Mary, Tony and Nancy were all covered in squirrels (including Chef Bill, Optinuts Prime, Emily's Daughter, All of Earth's Dark Matter, Elcid Barrett and Friday) to protect them. The Avengers attacked, having been alerted to the battle by the media, and Nancy helped Mary, who sought to take over Brain Drain's discarded armor after Brain Drain was freed from it. When the armor started working, Mary was thrilled and Iron Man considered giving her a job post-graduation. Soon, Squirrel Girl's allies arrived, including Ratatoskr, Rhino, Ms. Chloe, Kraven the Hunter, Sentinel X-42903-22, G'illian Blax'zthor, Hippo, Sootori, the Chrrt-Chuk, Mole Man, Chef Bear, the Tree Lobster and Alfredo the Chicken. When Dr. Doom announced he had set off a bomb to kill them all, they searched for it but SG threw herself on the bomb to save her friends.